MYELOID NEOPLASIA Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies
نویسندگان
چکیده
Tamer E. Fandy,1 James G. Herman,1 Patrick Kerns,1 Anchalee Jiemjit,1 Elizabeth A. Sugar,2 Si-Ho Choi,3 Allen S. Yang,3 Timothy Aucott,1 Tianna Dauses,1 Rosalie Odchimar-Reissig,4 Jonathan Licht,5 Melanie J. McConnell,6 Chris Nasrallah,7 Marianne K. H. Kim,5 Weijia Zhang,8 Yezou Sun,9 Anthony Murgo,10 Igor Espinoza-Delgado,10 Katharine Oteiza,1 Ibitayo Owoeye,1 Lewis R. Silverman,4 Steven D. Gore,1 and Hetty E. Carraway1
منابع مشابه
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies.
Sequential administration of DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors has demonstrated clinical efficacy in patients with hematologic malignancies. However, the mechanism behind their clinical efficacy remains controversial. In this study, the methylation dynamics of 4 TSGs (p15(INK4B), CDH-1, DAPK-1, and SOCS-1) were studied in sequential bone marrow sa...
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More than 60 years after the first description of differentiation in cell culture and 40 years after the synthesis of 5-azacytidine, epigenetic therapies have been added to the anticancer armamentarium. DNA methyltransferase (DNMT) inhibitors such as 5-aza-2'-deoxycytidine or 5-azacytidine have been approved in myelodysplastic syndrome (MDS) and acute myelogenous leukemia (AML), whereas the his...
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